Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice

Modest elevations in C-reactive protein (CRP) are associated with type 2 diabetes. We previously revealed in mice that increased CRP causes insulin resistance and mice globally deficient in the CRP receptor Fcγ receptor IIB (FcγRIIB) were protected from the disorder. FcγRIIB is expressed in numerous...

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Veröffentlicht in:Diabetes
Hauptverfasser: Tanigaki, Keiji, Chambliss, Ken L., Yuhanna, Ivan S., Sacharidou, Anastasia, Ahmed, Mohamed, Atochin, Dmitriy N., Huang, Paul L., Shaul, Philip W., Mineo, Chieko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2016
Schlagworte:
Pathophysiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915578/
https://ncbi.nlm.nih.gov/pubmed/27207525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1605
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