AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation

Previous investigations suggested that lamin A/C gene (LMNA) mutations, which cause a variety of human diseases including muscular dystrophies and cardiomyopathies, alter the nuclear mechanical properties. We hypothesized that biomechanical changes may extend beyond the nucleus.

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Bibliografische gegevens
Gepubliceerd in:Nucleus
Hoofdauteurs: Lanzicher, Thomas, Martinelli, Valentina, Long, Carlin S, Del Favero, Giorgia, Puzzi, Luca, Borelli, Massimo, Mestroni, Luisa, Taylor, Matthew R G, Sbaizero, Orfeo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915516/
https://ncbi.nlm.nih.gov/pubmed/26309016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2015.1084453
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