Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms

Depression has been associated with abnormalities in glutamatergic neurotransmission and decreased astrocyte number in limbic areas. We previously demonstrated that global and prefrontal cortical blockade of the astrocytic glutamate transporter (GLT-1) induces anhedonia and c-Fos expression in areas...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: John, Catherine S, Sypek, Elizabeth I, Carlezon, William A, Cohen, Bruce M, Öngür, Dost, Bechtholt, Anita J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915252/
https://ncbi.nlm.nih.gov/pubmed/25586634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.16
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