Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia

Major depression is associated with both dysregulated glutamatergic neurotransmission and fewer astrocytes in limbic areas including the prefrontal cortex (PFC). These deficits may be functionally related. Notably, astrocytes regulate glutamate levels by removing glutamate from the synapse via the g...

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Autori principali: John, Catherine S, Smith, Karen L, Van'T Veer, Ashlee, Gompf, Heinrich S, Carlezon, William A, Cohen, Bruce M, Öngür, Dost, Bechtholt-Gompf, Anita J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442341/
https://ncbi.nlm.nih.gov/pubmed/22739467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.105
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