Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia

Major depression is associated with both dysregulated glutamatergic neurotransmission and fewer astrocytes in limbic areas including the prefrontal cortex (PFC). These deficits may be functionally related. Notably, astrocytes regulate glutamate levels by removing glutamate from the synapse via the g...

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Detalhes bibliográficos
Main Authors: John, Catherine S, Smith, Karen L, Van'T Veer, Ashlee, Gompf, Heinrich S, Carlezon, William A, Cohen, Bruce M, Öngür, Dost, Bechtholt-Gompf, Anita J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442341/
https://ncbi.nlm.nih.gov/pubmed/22739467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.105
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