Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Interstitial fibrosis represents a key pathological process in non-alcoholic steatohepatitis (NASH). In the liver, fibrogenesis is primarily mediated by activated hepatic stellate cells (HSCs) transitioning from a quiescent state in response to a host of stimuli. The molecular mechanism underlying H...

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Vydáno v:Sci Rep
Hlavní autoři: Sun, Lina, Fan, Zhiwen, Chen, Junliang, Tian, Wenfang, Li, Min, Xu, Huihui, Wu, Xiaoyan, Shao, Jing, Bian, Yaoyao, Fang, Mingming, Xu, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914937/
https://ncbi.nlm.nih.gov/pubmed/27323886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28432
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