Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries

High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that converge on perturbed thyroid hormone (TH) homeostasis. Screening for MIEs specific to TH-disrupting pathways is limited in the U.S. Environmen...

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Udgivet i:Toxicol Sci
Main Authors: Paul Friedman, Katie, Watt, Eric D., Hornung, Michael W., Hedge, Joan M., Judson, Richard S., Crofton, Kevin M., Houck, Keith A., Simmons, Steven O.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
ToxCast Screening of Thyroperoxidase Inhibitors
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914804/
https://ncbi.nlm.nih.gov/pubmed/26884060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw034
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