Synergy between Colistin and the Signal Peptidase Inhibitor MD3 Is Dependent on the Mechanism of Colistin Resistance in Acinetobacter baumannii

Synergy between colistin and the signal peptidase inhibitor MD3 was tested against isogenic mutants and clinical pairs of Acinetobacter baumannii isolates. Checkerboard assays and growth curves showed synergy against both colistin-susceptible strains (fractional inhibitory concentration index [FIC(i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Martínez-Guitián, Marta, Vázquez-Ucha, Juan C., Odingo, Joshua, Parish, Tanya, Poza, Margarita, Waite, Richard D., Bou, German, Wareham, David W., Beceiro, Alejandro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2016
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914650/
https://ncbi.nlm.nih.gov/pubmed/27139471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00510-16
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