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Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline

Mobile elements comprise a major fraction of most mammalian genomes. To protect their fitness and stability, hosts must keep mobile elements in check in their germline. In most tissues mobile element insertions are decorated with chromatin modifications suggestive of transcriptional silencing. Howev...

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Detalhes bibliográficos
Publicado no:Curr Opin Genet Dev
Main Authors: Molaro, Antoine, Malik, Harmit S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914476/
https://ncbi.nlm.nih.gov/pubmed/26821364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2015.12.001
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