Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy

Cancer testis antigens (CTAs) are promising cancer associated antigens in solid tumors, but in acute myeloid leukemia, dense promoter methylation silences their expression. Leukemia cell lines exposed to HMAs induce expression of CTAs. We hypothesized that AML patients treated with standard of care...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Srivastava, Pragya, Paluch, Benjamin E., Matsuzaki, Junko, James, Smitha R., Collamat-Lai, Golda, Blagitko-Dorfs, Nadja, Ford, Laurie Ann, Naqash, Rafeh, Lübbert, Michael, Karpf, Adam R., Nemeth, Michael J., Griffiths, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914325/
https://ncbi.nlm.nih.gov/pubmed/26883197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7326
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