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Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells
Decitabine (5-aza-2′-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic drug for the therapy of myeloid leukemias. The mode of action of decitabine strictly depends on the incorporation of the drug into DNA. However, DNA incorporation and ensuing genotoxic effects of de...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4231731/ https://ncbi.nlm.nih.gov/pubmed/25159616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku775 |
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