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Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells
Decitabine (5-aza-2′-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic drug for the therapy of myeloid leukemias. The mode of action of decitabine strictly depends on the incorporation of the drug into DNA. However, DNA incorporation and ensuing genotoxic effects of de...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4231731/ https://ncbi.nlm.nih.gov/pubmed/25159616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku775 |
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