Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

Camptothecin (CPT) and its analogues are chemotherapeutic agents that covalently and reversibly link DNA Topoisomerase I to its nicked DNA intermediate eliciting the formation of DNA double strand breaks (DSB) during replication. The repair of these DSB involves multiple DNA damage response and repa...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Tripathi, Kaushlendra, Mani, Chinnadurai, Clark, David W, Palle, Komaraiah
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914303/
https://ncbi.nlm.nih.gov/pubmed/26871286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7247
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