PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells

The protein phosphatase 2A (PP2A) inhibitor, LB100, has been shown in pre-clinical studies to be an effective chemo- and radio-sensitizer for treatment of various cancers. We investigated effects associated with LB100 treatment alone and in combination with cisplatin for medulloblastoma (MB) in vitr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ho, Winson S., Feldman, Michael J., Maric, Dragan, Amable, Lauren, Hall, Matthew D., Feldman, Gerald M., Ray-Chaudhury, Abhik, Lizak, Martin J., Vera, Juan-Carlos, Robison, R. Aaron, Zhuang, Zhengping, Heiss, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914297/
https://ncbi.nlm.nih.gov/pubmed/26799670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6970
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