Cre-dependent DNA recombination activates a STING-dependent innate immune response

Gene-recombinase technologies, such as Cre/loxP-mediated DNA recombination, are important tools in the study of gene function, but have potential side effects due to damaging activity on DNA. Here we show that DNA recombination by Cre instigates a robust antiviral response in mammalian cells, indepe...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Pépin, Geneviève, Ferrand, Jonathan, Höning, Klara, Jayasekara, W. Samantha N., Cain, Jason E., Behlke, Mark A., Gough, Daniel J., G. Williams, Bryan R., Hornung, Veit, Gantier, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914124/
https://ncbi.nlm.nih.gov/pubmed/27166376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw405
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