Cortical Dopamine Transmission as Measured with the [(11)C]FLB 457 – Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype

Basic investigations link a Val158Met polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene to not only its enzymatic activity, but also to its dopaminergic tone in the prefrontal cortex. Previous PET studies have documented the relationship between COMT Val158Met polymorphism and D(...

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Foilsithe in:PLoS One
Main Authors: Narendran, Rajesh, Tumuluru, Divya, May, Maureen A., Chowdari, Kodavali V., Himes, Michael L., Fasenmyer, Kelli, Frankle, W. Gordon, Nimgaonkar, Vishwajit L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913897/
https://ncbi.nlm.nih.gov/pubmed/27322568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157867
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