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Do Mechanical Strain and TNF-α Interact To Amplify Pro-Inflammatory Cytokine Production in Human Annulus Fibrosus Cells?
During intervertebral disc (IVD) injury and degeneration, annulus fibrosus (AF) cells experience large mechanical strains in a pro-inflammatory milieu. We hypothesized that TNF-α, an initiator of IVD inflammation, modifies AF cell mechanobiology via cytoskeletal changes, and interacts with mechanica...
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| Udgivet i: | J Biomech |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4913356/ https://ncbi.nlm.nih.gov/pubmed/26924657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2016.02.029 |
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