Do Mechanical Strain and TNF-α Interact To Amplify Pro-Inflammatory Cytokine Production in Human Annulus Fibrosus Cells?

During intervertebral disc (IVD) injury and degeneration, annulus fibrosus (AF) cells experience large mechanical strains in a pro-inflammatory milieu. We hypothesized that TNF-α, an initiator of IVD inflammation, modifies AF cell mechanobiology via cytoskeletal changes, and interacts with mechanica...

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Foilsithe in:J Biomech
Main Authors: Likhitpanichkul, Morakot, Torre, Olivia M, Gruen, Jadry, Walter, Benjamin A, Hecht, Andrew C, Iatridis, James C
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913356/
https://ncbi.nlm.nih.gov/pubmed/26924657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2016.02.029
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