Crystal structure of MytiLec, a galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types

MytiLec is a lectin, isolated from bivalves, with cytotoxic activity against cancer cell lines that express globotriaosyl ceramide, Galα(1,4)Galβ(1,4)Glcα1-Cer, on the cell surface. Functional analysis shows that the protein binds to the disaccharide melibiose, Galα(1,6)Glc, and the trisaccharide gl...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Terada, Daiki, Kawai, Fumihiro, Noguchi, Hiroki, Unzai, Satoru, Hasan, Imtiaj, Fujii, Yuki, Park, Sam-Yong, Ozeki, Yasuhiro, Tame, Jeremy R. H.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913266/
https://ncbi.nlm.nih.gov/pubmed/27321048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28344
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