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Maytansinoid immunoconjugate IMGN901 is cytotoxic in a three-dimensional culture model of multiple myeloma

Environmental-mediated drug-resistance (EM-DR) presents a major challenge for therapeutic development. Tissue microenvironment in the form of extracellular matrix, soluble factors, and stroma contribute to EM-DR. In multiple myeloma (MM), drug-resistance has hindered treatment success with 5-year su...

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Détails bibliographiques
Publié dans:Am J Blood Res
Auteurs principaux: Nierste, Brittany A, Gunn, Ellen J, Whiteman, Kathleen R, Lutz, Robert J, Kirshner, Julia
Format: Artigo
Langue:Inglês
Publié: e-Century Publishing Corporation 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913235/
https://ncbi.nlm.nih.gov/pubmed/27335686
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