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Structural characterization of the maytansinoid–monoclonal antibody immunoconjugate, huN901–DM1, by mass spectrometry

Immunoconjugates are being explored as novel cancer therapies with the promise of target-specific drug delivery. The immunoconjugate, huN901–DM1, composed of the humanized monoclonal IgG(1) antibody, huN901, and the maytansinoid drug, DM1, is being tested in clinical trials to treat small cell lung...

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Detalles Bibliográficos
Main Authors: Wang, Lintao, Amphlett, Godfrey, Blättler, Walter A., Lambert, John M., Zhang, Wei
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253466/
https://ncbi.nlm.nih.gov/pubmed/16081651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051478705
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