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CSF-1R–dependent lethal hepatotoxicity when agonistic CD40 antibody given before but not after chemotherapy

Cancer immunotherapies are increasingly effective in the clinic, especially immune checkpoint blockade delivered to patients who have T cell-infiltrated tumors. Agonistic CD40 mAb promotes stromal degradation, and in combination with chemotherapy, drives T cell infiltration and de novo responses aga...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Byrne, Katelyn T., Leisenring, Nathan H., Bajor, David L., Vonderheide, Robert H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912938/
https://ncbi.nlm.nih.gov/pubmed/27217585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600146
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