Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator

Synthetic cathinones produce dysregulation of monoamine systems, but their effects on the glutamate system and the influence of glutamate on behavioral effects related to cathinone abuse are unknown. A principal regulator of glutamate homeostasis is glutamate transporter subtype 1 (GLT-1), an astroc...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Gregg, Ryan A., Hicks, Callum, Nayak, Sunil U., Tallarida, Christopher S., Nucero, Paul, Reitz, Allen B., Smith, Garry R., Rawls, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912874/
https://ncbi.nlm.nih.gov/pubmed/27085607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.04.014
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