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Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of drugs for treatin...

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Bibliografische gegevens
Gepubliceerd in:Pathobiol Aging Age Relat Dis
Hoofdauteurs: Keene, C. Dirk, Darvas, Martin, Kraemer, Brian, Liggitt, Denny, Sigurdson, Christina, Ladiges, Warren
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Co-Action Publishing 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912600/
https://ncbi.nlm.nih.gov/pubmed/27317189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/pba.v6.32397
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