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Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of drugs for treatin...

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Foilsithe in:Pathobiol Aging Age Relat Dis
Main Authors: Keene, C. Dirk, Darvas, Martin, Kraemer, Brian, Liggitt, Denny, Sigurdson, Christina, Ladiges, Warren
Formáid: Artigo
Teanga:Inglês
Foilsithe: Co-Action Publishing 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912600/
https://ncbi.nlm.nih.gov/pubmed/27317189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/pba.v6.32397
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