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Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy of drugs for treatin...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pathobiol Aging Age Relat Dis
Prif Awduron: Keene, C. Dirk, Darvas, Martin, Kraemer, Brian, Liggitt, Denny, Sigurdson, Christina, Ladiges, Warren
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Co-Action Publishing 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912600/
https://ncbi.nlm.nih.gov/pubmed/27317189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/pba.v6.32397
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