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Reactive Oxygen Species Production in Cardiac Mitochondria After Complex I Inhibition: Modulation by Substrate-Dependent Regulation of the NADH/NAD(+) Ratio

Reactive oxygen species (ROS) production by isolated complex I is steeply dependent on the NADH/NAD(+) ratio. We used alamethicin-permeabilized mitochondria to study the substrate-dependence of matrix NADH and ROS production when complex I is inhibited by piericidin or rotenone. When complex I was i...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Korge, Paavo, Calmettes, Guillaume, Weiss, James N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912463/
https://ncbi.nlm.nih.gov/pubmed/27068062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.04.002
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