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Metabolite concentrations, fluxes, and free energies imply efficient enzyme usage
In metabolism, available free energy is limited and must be divided across pathway steps to maintain ΔG negative throughout. For each reaction, ΔG is log-proportional both to a concentration ratio (reaction quotient-to-equilibrium constant) and to a flux ratio (backward-to-forward flux). Here we use...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4912430/ https://ncbi.nlm.nih.gov/pubmed/27159581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2077 |
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