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Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition

The ability to routinely engineer protease specificity can allow us to better understand and modulate their biology for expanded therapeutic and industrial applications. Here we report a new approach based on a caged green fluorescent protein (CA-GFP) reporter that allows for flow-cytometry-based se...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Chem Biol
मुख्य लेखकों: Hill, Maureen E., MacPherson, Derek J., Wu, Peng, Julien, Olivier, Wells, James A., Hardy, Jeanne A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912419/
https://ncbi.nlm.nih.gov/pubmed/27032039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00971
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