LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncanonical glutamine pathway that is reliant on...

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Vydáno v:Genes Dev
Hlavní autoři: Xu, Pan, Oosterveer, Maaike H., Stein, Sokrates, Demagny, Hadrien, Ryu, Dongryeol, Moullan, Norman, Wang, Xu, Can, Emine, Zamboni, Nicola, Comment, Arnaud, Auwerx, Johan, Schoonjans, Kristina
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911925/
https://ncbi.nlm.nih.gov/pubmed/27298334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.277483.116
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