Highly potent intracellular membrane-associated Aβ seeds

An early event in Alzheimer’s disease (AD) pathogenesis is the formation of extracellular aggregates of amyloid-β peptide (Aβ), thought to be initiated by a prion-like seeding mechanism. However, the molecular nature and location of the Aβ seeds remain rather elusive. Active Aβ seeds are found in cr...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Marzesco, Anne-Marie, Flötenmeyer, Matthias, Bühler, Anika, Obermüller, Ulrike, Staufenbiel, Matthias, Jucker, Mathias, Baumann, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911570/
https://ncbi.nlm.nih.gov/pubmed/27311744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28125
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