Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines

Pten negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway and is required to maintain quiescent adult hematopoietic stem cells (HSCs). Pten has been proposed to regulate HSCs cell autonomously and non-cell autonomously, but the relative importance of each mechanism has not been dire...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Porter, Shaina N., Cluster, Andrew S., Signer, Robert A.J., Voigtmann, Jenna, Monlish, Darlene A., Schuettpelz, Laura G., Magee, Jeffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911494/
https://ncbi.nlm.nih.gov/pubmed/27185281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.04.008
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