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Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines

Summary: Pten negatively regulates the phosphatidylinositol 3-kinase (PI3K) pathway and is required to maintain quiescent adult hematopoietic stem cells (HSCs). Pten has been proposed to regulate HSCs cell autonomously and non-cell autonomously, but the relative importance of each mechanism has not...

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Auteurs principaux: Shaina N. Porter, Andrew S. Cluster, Robert A.J. Signer, Jenna Voigtmann, Darlene A. Monlish, Laura G. Schuettpelz, Jeffrey A. Magee
Format: Artigo
Langue:Inglês
Publié: Elsevier 2016-06-01
Collection:Stem Cell Reports
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2213671116300339
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