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HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection
The main function of HLA class I molecules is to present pathogen-derived peptides to cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an extraordinary amount of polymorphism at each HLA locus, providing an immune advantage to heterozygote individuals capable to present...
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| Veröffentlicht in: | Immunogenetics |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Berlin Heidelberg
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4911380/ https://ncbi.nlm.nih.gov/pubmed/27233953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-016-0918-x |
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