Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach

New antimycotic drugs are challenging to find, as potential target proteins may have close human orthologs. We here focus on identifying metabolic targets that are critical for fungal growth and have minimal similarity to targets among human proteins. We compare and combine here: (I) direct metaboli...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Kaltdorf, Martin, Srivastava, Mugdha, Gupta, Shishir K., Liang, Chunguang, Binder, Jasmin, Dietl, Anna-Maria, Meir, Zohar, Haas, Hubertus, Osherov, Nir, Krappmann, Sven, Dandekar, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911368/
https://ncbi.nlm.nih.gov/pubmed/27379244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00022
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