Vaccination with Irradiated Autologous Tumor Cells Mixed with Irradiated GM-K562 Cells Stimulates Anti-tumor Immunity and T Lymphocyte Activation in Patients with Recurrent Malignant Glioma

PURPOSE: Recurrent malignant glioma carries a dismal prognosis, and novel therapies are needed. We examined the feasibility and safety of vaccination with irradiated autologous glioma cells mixed with irradiated GM-K562 cells in patients undergoing craniotomy for recurrent malignant glioma. PATIENTS...

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Publicado no:Clin Cancer Res
Main Authors: Curry, William T., Gorrepati, Ramana, Piesche, Matthias, Sasada, Tetsuro, Agarwalla, Pankaj, Jones, Pamela S., Gerstner, Elizabeth R., Golby, Alexandra J., Batchelor, Tracy T., Wen, Patrick Y., Mihm, Martin C., Dranoff, Glenn
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911283/
https://ncbi.nlm.nih.gov/pubmed/26873960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2163
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