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Sequential Immunotherapy by Vaccination with GM-CSF Expressing Glioma Cells and CTLA-4 Blockade Effectively Treats Established Murine Intracranial Tumors

Malignant glioma is an incurable disease with a relatively short median survival. Several clinical trials have demonstrated that immunotherapy with vaccination is a safe and possibly effective way of prolonging survival. Antibody-based blockade of CTLA-4 ligation on T lymphocytes is associated with...

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Detalhes bibliográficos
Main Authors: Agarwalla, Pankaj, Barnard, Zachary, Fecci, Peter, Dranoff, Glenn, Curry, William T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352987/
https://ncbi.nlm.nih.gov/pubmed/22576343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182562d59
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