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MET Exon 14 Alterations in Lung Cancer: Exon Skipping Extends Half-Life

MET exon 14 alterations are a diverse group of mutations, many of which disrupt splice acceptor or donor sites leading to exon 14 skipping, impaired receptor degradation, and oncogenic transformation. These alterations are clinically targetable with MET-directed therapy.

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Hovedforfatter: Drilon, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911276/
https://ncbi.nlm.nih.gov/pubmed/27009743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0229
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