Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

Mutations in the MET exon 14 RNA splice acceptor and donor sites, which lead to exon skipping, deletion of the juxtamembrane domain containing the Cbl E3-ubiquitin ligase binding site, and decreased turnover of the resultant aberrant MET protein, were previously reported to be oncogenic in preclinic...

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Udgivet i:Cancer Discov
Main Authors: Paik, Paul K., Drilon, Alexander, Fan, Pang-Dian, Yu, Helena, Rekhtman, Natasha, Ginsberg, Michelle S., Borsu, Laetitia, Schultz, Nikolaus, Berger, Michael F., Rudin, Charles M., Ladanyi, Marc
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658654/
https://ncbi.nlm.nih.gov/pubmed/25971939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1467
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