Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women

BACKGROUND: Rilpivirine pharmacokinetics are defined by its absorption, distribution, metabolism, and excretion. Pregnancy can affect these factors by changes in cardiac output, protein binding, volume of distribution, and cytochrome P450 (CYP) 3A4 activity. Rilpivirine is metabolized by CYP3A4. The...

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Bibliografiske detaljer
Udgivet i:J Acquir Immune Defic Syndr
Main Authors: Tran, Anna Hoang, Best, Brookie M., Stek, Alice, Wang, Jiajia, Capparelli, Edmund V., Burchett, Sandra K., Kreitchmann, Regis, Rungruengthanakit, Kittipong, George, Kathleen, Cressey, Tim R., Chakhtoura, Nahida, Smith, Elizabeth, Shapiro, David E., Mirochnick, Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911231/
https://ncbi.nlm.nih.gov/pubmed/26918544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000968
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