Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women

BACKGROUND: Rilpivirine pharmacokinetics are defined by its absorption, distribution, metabolism, and excretion. Pregnancy can affect these factors by changes in cardiac output, protein binding, volume of distribution, and cytochrome P450 (CYP) 3A4 activity. Rilpivirine is metabolized by CYP3A4. The...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Tran, Anna Hoang, Best, Brookie M., Stek, Alice, Wang, Jiajia, Capparelli, Edmund V., Burchett, Sandra K., Kreitchmann, Regis, Rungruengthanakit, Kittipong, George, Kathleen, Cressey, Tim R., Chakhtoura, Nahida, Smith, Elizabeth, Shapiro, David E., Mirochnick, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911231/
https://ncbi.nlm.nih.gov/pubmed/26918544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000000968
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