JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE

BACKGROUND: Although most studies on treatments for eosinophilic esophagitis (EoE) have focused on effects in the epithelium, EoE is a transmural disease. Eosinophils that infiltrate the subepithelial layers of the esophagus lead to fibrosis and the serious complications of EoE, and current therapie...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Cheng, Edaire, Zhang, Xi, Wilson, Kathleen S., Wang, David H., Park, Jason Y., Huo, Xiaofang, Yu, Chunhua, Zhang, Qiuyang, Spechler, Stuart J., Souza, Rhonda F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911010/
https://ncbi.nlm.nih.gov/pubmed/27310888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157376
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