Proton Pump Inhibitors Decrease Eotaxin-3 Expression in the Proximal Esophagus of Children with Esophageal Eosinophilia

OBJECTIVE: Besides reducing gastric acid secretion, proton pump inhibitors (PPIs) suppress Th2-cytokine-stimulated expression of an eosinophil chemoattractant (eotaxin-3) by esophageal epithelial cells through acid-independent, anti-inflammatory mechanisms. To explore acid-inhibitory and acid-indepe...

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Main Authors: Park, Jason Y., Zhang, Xi, Nguyen, Nathalie, Souza, Rhonda F., Spechler, Stuart J., Cheng, Edaire
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079672/
https://ncbi.nlm.nih.gov/pubmed/24988451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101391
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