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Melanoma driver mutations and immune therapy

Melanoma harbors recurrent oncogenic driver mutations in BRAF and NRAS, but these mutations' impact on immunotherapy outcomes is unclear. We assessed 229 patients treated with immunotherapy, and found that clinical outcomes were largely superior in those with NRAS mutations. Herein, we discuss...

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Udgivet i:Oncoimmunology
Main Authors: Johnson, Douglas B., Lovly, Christine M., Sullivan, Ryan J., Carvajal, Richard D., Sosman, Jeffrey A.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910708/
https://ncbi.nlm.nih.gov/pubmed/27467925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1051299
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