Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors

PURPOSE: An association between mutational burden and response to immune checkpoint therapy has been documented in several cancer types. The potential for such a mutational burden threshold to predict response to immune checkpoint therapy was evaluated in several clinical datasets, where mutational...

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Bibliografische gegevens
Gepubliceerd in:JCO Precis Oncol
Hoofdauteurs: Panda, Anshuman, Betigeri, Anil, Subramanian, Kalyanasundaram, Ross, Jeffrey S., Pavlick, Dean C., Ali, Siraj, Markowski, Paul, Silk, Ann, Kaufman, Howard L., Lattime, Edmund, Mehnert, Janice M., Sullivan, Ryan, Lovly, Christine M., Sosman, Jeffrey, Johnson, Douglas B., Bhanot, Gyan, Ganesan, Shridar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Clinical Oncology 2017
Onderwerpen:
Original Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016848/
https://ncbi.nlm.nih.gov/pubmed/29951597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.17.00146
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