Impact of NRAS mutations for patients with advanced melanoma treated with immune therapies

Activating NRAS mutations are found in 15-20% of melanomas. Immune therapies have become a mainstay in advanced melanoma treatment. We sought to evaluate whether tumor genotype (e.g. NRAS mutations) correlate with benefit from immune therapy in melanoma. We identified 229 melanoma patients treated w...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Johnson, Douglas B., Lovly, Christine M., Flavin, Marisa, Panageas, Katherine S., Ayers, Gregory D., Zhao, Zhiguo, Iams, Wade T., Colgan, Marta, DeNoble, Sarah, Terry, Charles R., Berry, Elizabeth G., Iafrate, A. John, Sullivan, Ryan J., Carvajal, Richard D., Sosman, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351797/
https://ncbi.nlm.nih.gov/pubmed/25736262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0207
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