Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.
The properties of naiveté and large diversity are considered to be essential starting features for combinatorial antibody libraries that eschew immunization by evolution in vitro. We have prepared large libraries with such properties by using random oligonucleotide synthesis, which has the potential...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49101/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4457 |
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