Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.

The properties of naiveté and large diversity are considered to be essential starting features for combinatorial antibody libraries that eschew immunization by evolution in vitro. We have prepared large libraries with such properties by using random oligonucleotide synthesis, which has the potential...

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Bibliographic Details
Main Authors: Barbas, C F, Bain, J D, Hoekstra, D M, Lerner, R A
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC49101/
https://ncbi.nlm.nih.gov/pubmed/1584777
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