A binary plasmid system for shuffling combinatorial antibody libraries.

We have used a binary system of replicon-compatible plasmids to test the potential for promiscuous recombination of heavy and light chains within sets of human Fab fragments isolated from combinatorial antibody libraries. Antibody molecules showed a surprising amount of promiscuity in that a particu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Collet, T A, Roben, P, O'Kennedy, R, Barbas, C F, Burton, D R, Lerner, R A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50270/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438192/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10026
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