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A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo–YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the tran...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Qi, Yangfan, Yu, Jing, Han, Wei, Fan, Xiaojuan, Qian, Haili, Wei, Huanhuan, Tsai, Yi-hsuan S., Zhao, Jinyao, Zhang, Wenjing, Liu, Quentin, Meng, Songshu, Wang, Yang, Wang, Zefeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909989/
https://ncbi.nlm.nih.gov/pubmed/27291620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11840
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