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A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo–YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the tran...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909989/ https://ncbi.nlm.nih.gov/pubmed/27291620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11840 |
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