A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo–YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the tran...

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Pubblicato in:Nat Commun
Autori principali: Qi, Yangfan, Yu, Jing, Han, Wei, Fan, Xiaojuan, Qian, Haili, Wei, Huanhuan, Tsai, Yi-hsuan S., Zhao, Jinyao, Zhang, Wenjing, Liu, Quentin, Meng, Songshu, Wang, Yang, Wang, Zefeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909989/
https://ncbi.nlm.nih.gov/pubmed/27291620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11840
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