A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo–YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the tran...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Qi, Yangfan, Yu, Jing, Han, Wei, Fan, Xiaojuan, Qian, Haili, Wei, Huanhuan, Tsai, Yi-hsuan S., Zhao, Jinyao, Zhang, Wenjing, Liu, Quentin, Meng, Songshu, Wang, Yang, Wang, Zefeng
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909989/
https://ncbi.nlm.nih.gov/pubmed/27291620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11840
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk