A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo–YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the tran...

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Publicado en:Nat Commun
Autores principales: Qi, Yangfan, Yu, Jing, Han, Wei, Fan, Xiaojuan, Qian, Haili, Wei, Huanhuan, Tsai, Yi-hsuan S., Zhao, Jinyao, Zhang, Wenjing, Liu, Quentin, Meng, Songshu, Wang, Yang, Wang, Zefeng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909989/
https://ncbi.nlm.nih.gov/pubmed/27291620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11840
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