Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects

The curly tail mouse provides a model for neural tube defects (spina bifida and exencephaly) that are resistant to prevention by folic acid. The major ct gene, responsible for spina bifida, corresponds to a hypomorphic allele of grainyhead-like 3 (Grhl3) but the frequency of NTDs is strongly influen...

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Dettagli Bibliografici
Pubblicato in:Biochimie
Autori principali: Sudiwala, Sonia, De Castro, Sandra C.P., Leung, Kit-Yi, Brosnan, John T., Brosnan, Margaret E., Mills, Kevin, Copp, Andrew J., Greene, Nicholas D.E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Editions Scientifiques Elsevier 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909716/
https://ncbi.nlm.nih.gov/pubmed/26924399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2016.02.010
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